Type 1 diabetes cases will continue to increase across all analyzed countries, although limitations in the understanding of etiology make prevention difficult.
By Nicola Leckenby, Epidemiologist
10 May 2016
I joined Datamonitor Healthcare as an Epidemiologist in 2015. Prior to this, I obtained an MSc (with Distinction) in Pub...
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The burden of type 1 diabetes, although substantial, is small compared to type 2 diabetes.
Type 1 diabetes is a heterogeneous disorder characterized by destruction of pancreatic beta cells, and accounts for approximately 5–10% of all diabetes cases. Type 1 diabetes is typically diagnosed in children, but can also present in adults. Risk factors include genetic factors, autoimmune disease and certain environmental exposures. Although the discovery of insulin has improved prognosis considerably, affected individuals continue to experience higher morbidity and mortality compared to the non-diabetic population and the type 2 diabetic population.
Datamonitor Healthcare estimates that in 2015, there were approximately 5.0 million total prevalent cases of type 1 diabetes in individuals of all ages in the US, Japan, and five major EU markets (France, Germany, Italy, Spain, and the UK). Datamonitor Healthcare expects total prevalent cases to increase in these analyzed markets across the forecast period (2015–35), although the magnitude of change varies across countries.
The etiology and pathogenesis of type 1 diabetes is yet to be fully deciphered, which makes prevention difficult
Identification of patients at risk of type 1 diabetes and interventions to slow or halt autoimmune beta cell destruction are still the focus of intense investigation. Indeed, over the past few decades, significant research efforts have been directed at finding the underlying causes of type 1 diabetes, with the aim of developing approaches for prevention and treatment. However, future attempts to prevent or ‘cure’ type 1 diabetes are dependent upon the evolving understanding of the complex pathogenesis of the disease, and the complex interaction between genetic and environmental risk is yet to be fully understood. As such, there is currently no way of preventing the disease.
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